Biographical Information

Research Interests

Due to their high specific interaction with their counter-receptors and their carefully regulated expression (limit to inflammation), leukocyte-endothelium adhesion molecules (LECAM) are attractive molecules for vascular targeting in human diseases in which inflammation plays a role. Our research goal is to use knowledge of the cellular inflammatory response and blood flow dynamics to design bio-functionalized particles for targeted drug delivery and imaging.

Work in the lab is divided into 3 major groups:

1. Cell Adhesion and Migration - Cells of the immune system.
   Our goal is to use in vitro experimental setups to understand the receptor-ligand interactions involved in leukocyte firm arrest and transmigration.
2. Design of polymeric cells for targeted drug delivery. We are working on designing sophisticated leukocyte mimetics that can target therapeutics to diseased vasculature via multiple receptor-ligand interactions with applications in cardiovascular disease and cancer.
3. Smart Biomaterials for Drug Delivery. We working closely with polymer chemists and material scientist to identify new materials for drug delivery. Our work in this area is currently focused on immune response to new materials.

Recent Publications

1. Huang, R.B. and O. Eniola-Adefeso.  Differential expression of E-selectin in shear-cytokine stimulated endothelial cells. In preparation.

2. Charoenphol, P., S. Mocherla, D. Dubois, K. Namdee and O. Eniola-Adefeso. Targeting Therapeutics to the Vascular Wall in Atherosclerosis - Carrier Size Matters. Atherosclerosis, 2011.  Submitted.

3. Huang, R.B., S. Mocherla, M.J. Heslinga, P. Charoenphol, and O. Eniola-Adefeso.  Dynamic and cellular interactions of nanoparticles in vascular-targeted drug delivery.  Mol Membr Biol, 2010.  27(4-6):190-205.  Second most read article - summer 2010.

4. Eniola-Adefeso, O. Bringing Outreach Into the Engineering Classroom – A Mass and Heat Transfer Course Project.  Chem Eng Ed, 2010. In Print.

5. Charoenphol, P., R.B. Huang and O. Eniola-Adefeso. Roles of particle size and hemodynamics on the efficacy of spherical vascular-targeted drug carriers. Biomaterials, 2010.  31(6):1392-402.

6. Heslinga, M.J., E.M. Mastria and O. Eniola-Adefeso. Fabrication of biodegradable spheroidal microparticles for drug delivery applications. J Control Release, 2009. 138(3):235-242.

7. Eniola-Adefeso, O., R.B. Huang and C.W. Smith. Kinetics of LFA-1 Mediated Adhesion of Human Neutrophils to ICAM-1 – Role of E-Selectin Signaling Post-Activation. Annals of Biomed Eng, 2009. 37(4):737-48.

8. Eniola, A.O. and D.A. Hammer. In vitro characterization of leukocyte mimetic for targeting therapeutics to the endothelium using two receptors. Biomaterials, 2005. 26(34):7136-44.

9. Eniola, A.O., E.F. Krasik, L.A. Smith, S. Gang, and D.A. Hammer. I-domain of lymphocyte function-associated antigen-1 mediates rolling of polystyrene particles on ICAM-1 under flow.  Biophysical Journal, 2005. 89:3577-88.

10. Eniola, A.O. and D.A. Hammer. Characterization of biodegradable drug delivery vehicles with the adhesive properties of leukocytes II: Effect of degradation on targeting efficiency. Biomaterials, 2005. 26(6):661-670         

11. Eniola, A.O., P.J. Willcox and D.A. Hammer. Quantifying Interplay between rolling and firm adhesion elucidated with a cell-free system engineered with two distinct receptor-ligand pairs.  Biophysical Journal, 2003. 85(4):2720-31.

12. Zhang, Y., A.O. Eniola, D.J. Graves, and D.A. Hammer. Specific Adhesion of Micron-Sized Colloids to Surfaces Mediated by DNA Hybridization. Langmuir, 2003. 19(17):6905-11.

13. Eniola, A.O. and D.A. Hammer. Artificial polymeric cells for targeted drug delivery. J Controlled Release, 2003. 87(1-3):18-22.

14. Eniola, A.O., S.D. Rodgers and D.A. Hammer. Characterization of biodegradable drug delivery vehicles with the adhesive properties of leukocytes. Biomaterials, 2002. 23(10):2167-77.

15. Eniola, A.O. and J.A. Lumpkin. Reducing metal-catalyzed oxidation during immobilized Cu-Iminodiacetic acid metal affinity chromatography. Proceedings National Conference of Undergraduate Research, 1998. Volume III: 989-91.

Courses Taught at the University of Michigan

Undergraduate ChE Courses

ChE 230 - Material and Energy Balance, Fall 2009, Fall 2010
ChE 342 - Mass and Heat Transfer, Fall 2006, Fall 2007, Fall 2008


 Student Projects

Graduate ChE Courses

ChE 696 - Engineering Principle in Drug Delivery and Targeting, Winter 2010