Claudia Loebel
Assistant Professor (Courtesy)
Location
3045W NCRC, Bldg. 28
Primary Website
Education
Ph.D., Health Science and Technology, ETH Zurich (Zurich, Switzerland), 2016
M.D., Martin Luther University Halle-Wittenberg (Halle, Germany), 2011
Research Interests
Our work is inspired by the interface between materials science and regenerative engineering to address specific problems related to tissue development, repair, and regeneration. By developing mechanically and structurally dynamic biomaterials, microfabrication, and matrix manipulation techniques we aim to recreate complex cell-matrix interactions and model tissue morphogenesis and disease. The ultimate goal is to use these engineered systems to develop and translate more effective therapeutic treatments for diseases such as fibrotic, inflammatory, and congenital disorders. Our work currently focuses on developing engineered lung alveolar organoids, aiming to build models of acute and chronic pulmonary diseases and for personalized medicine.
Biography
Professional Experience
University of Michigan
Materials Science and Engineering
Chemical Engineering Department
Ann Arbor, Michigan
Assistant Professor, 2021-
Prior Professional Experience
Postdoctoral Fellow, Bioengineering, University of Pennsylvania, 2016-2021Medical Research Fellow, Orthopedic Surgery, AO Foundation (Davos, Switzerland), 2012
Awards
- NIH NHLBI Pathway to Independence Award (K99/R00), 2020-2021
- Vice Chair (Chair 2022), Society for Biomaterials, Young Scientist Group, 2020-2021
- ETH Silver Medal (awarded to high quality doctoral theses), 2018
- SNSF Early Postdoc Mobility Fellowship, 2017-2018
- SSBRM Research Award, Swiss Society for Biomaterials and Regenerative Medicine, 2017
- Julia Polak European Doctoral Award, European Society for Biomaterials, 2017
- IBSA Foundation for Scientific Research Fellowship Award, 2016
- Racquel Z. LeGeros Award, European Society for Biomaterials, 2015
Publications
Loebel, C.*; Kwon, M.*; Wang, C.; Han, L.; Mauck, R.L.; Burdick, J.A. (2020) Metabolic labeling to probe temporal changes in the pericellular matrix at the cell-hydrogel interface. Advanced Functional Materials, in press*equal contribution
Loebel, C.; Mauck, R.L.; and Burdick, J.A. (2019) Local nascent protein deposition and remodeling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels. Nature Materials, 18, 883-891
Loebel, C.; Ayoub A.; Galarraga J.H.; Kossover, O.; Simaan-Yameen, H.; Seliktar, D.; Burdick, J.A. (2019) Tailoring supramolecular guest-host hydrogel viscoelasticity with covalent fibrinogen double networks. Journal of Materials Chemistry B, 7, 1753-1760
Loebel, C. and Burdick, J.A. (2018) Engineering Stem and Stromal Cell Therapies for Musculoskeletal Tissue Repair. Cell Stem Cell, 22, 325-339
Loebel, C.*; Rodell, C.B.*; Chen, M.H.; Burdick, J.A. (2017)Shear-thinning and self-healing hydrogels as injectable therapeutics and for 3D-printing. Nature Protocols, 12(8), 1521-1541 *equal contribution
Loebel, C.; Szczesny, S. E.; Cosgrove, B. D.; Alini, M.; Zenobi-Wong, M.; Mauck, R. L.; Eglin, D. (2017) Crosslinking Chemistry of Tyramine-Modified Hyaluronan Hydrogels Alters Mesenchymal Stem Cell Early Attachment and Behavior. Biomacromolecules, 18(3), 855-864
Loebel, C.; Stauber, T.; D’Este, M.; Alini, M.; Zenobi-Wong, M.; Eglin, D. (2017) Fabrication of cell-compatible hyaluronan hydrogels with a wide range of biophysical properties through high tyramine functionalization.Journal of Materials Chemistry A, 5(12), 2355-2363
Li, B.; Menzel, U.; Loebel, C.; Schmal, H.; Alini, M.; Stoddart, M. J. (2016) Monitoring live human mesenchymal stromal cell differentiation and subsequent selection using fluorescent RNA-based probes. Scientific Reports, 6, 26014
Loebel, C.*; Broguiere, N.*; Alini, M.; Zenobi-Wong, M.; Eglin, D. (2015) Microfabrication of Photo-Cross-Linked Hyaluronan Hydrogels by Single- and Two-Photon Tyramine Oxidation. Biomacromolecules, 16(9), 2624-30 *equal contribution
Voss, J. O.; Loebel, C.; Bara, J. J.; Fussinger, M.A.; Duttenhoefer, F.; Alini, M.; Stoddart, M.J. (2015) Effect of Short-Term Stimulation with Interleukin-1beta and Differentiation Medium on Human Mesenchymal Stromal Cell Paracrine Activity in Coculture with Osteoblasts. BioMed Research International, 714230
Loebel, C.; D’Este, M.; Alini, M.; Zenobi-Wong, M.; Eglin, D. (2015) Precise tailoring of tyramine-based hyaluronan hydrogel properties using DMTMM conjugation. Carbohydrate Polymers, 115, 325-33
Loebel, C.; Czekanska, E.M.; Bruderer, M.; Salzmann, G.; Alini, M.; Stoddart, M.J. (2014) In vitro osteogenic potential of human mesenchymal stem cells is predicted by Runx2/Sox9 ratio. Tissue Engineering Part A, 21(1-2), 115-23
Loebel, C.; Czekanska, E.M.; Staudacher, J.; Salzmann, G.; Richards, R.G.; Alini, M.; Stoddart, M. J. (2014) The calcification potential of human MSCs can be enhanced by interleukin-1beta in osteogenic medium. Journal of Tissue Engineering and Regenerative Medicine, 11(2), 564-571
