Albert M. Mattocks Professor of Pharmaceutical Sciences and Chemical Engineering
Chemical Engineering
Pharmaceutical Sciences
B10-A179 NCRC
2800 Plymouth Road, Ann Arbor, MI 48109-2800(734) 763-1486
Ph.D. Chemical Engineering, University of Delaware, 2003
B.S. Chemical Engineering, University of Maine, 1998
The Tessier lab aims to develop next generation technologies for designing, discovering, engineering, characterizing, formulating and delivering biologics ranging from small affinity peptides to large monoclonal antibodies for molecular imaging, diagnostic and therapeutic applications. This interdisciplinary research program involves the use of experimental and computational approaches to generate new fundamental insights related to protein structure and function, molecular origins of protein-protein interactions, and sequence and structural determinants of key protein properties (stability, solubility, specificity and affinity). With an eye toward applications, the Tessier lab also develops novel high-throughput screening tools for discovering new biologics and identifying rare variants with drug-like properties for therapeutic applications.
Albert M. Mattocks (Endowed) Professor
Departments of Chemical Engineering, Pharmaceutical Sciences and Biomedical Engineering and Biointerfaces Institute
University of Michigan, Ann Arbor, MI, 2017-present
Richard Baruch M.D. Career Development (Endowed) Professor
Department of Chemical & Biological Engineering
Rensselaer Polytechnic Institute, Troy, NY, 2016-2017
Richard Baruch M.D. Career Development (Endowed) Associate Professor
Department of Chemical & Biological Engineering
Rensselaer Polytechnic Institute, Troy, NY, 2014-2016
Alexander von Humboldt Fellow
Max Planck Institute of Biochemistry
Martinsried, Germany, 2014-2015
Associate Professor
Department of Chemical & Biological Engineering
Rensselaer Polytechnic Institute, Troy, NY, 2013-2016
Assistant Professor
Department of Chemical & Biological Engineering
Rensselaer Polytechnic Institute, Troy, NY, 2007-2013
American Cancer Society Postdoctoral Fellow
Whitehead Institute for Biomedical Research (MIT), Cambridge, MA, 2003-2007
Advisor: Susan Lindquist
Academic Honors
Fellow, American Institute for Medical and Biological Engineering, 2018
Young Investigator Award, Biochemical Engineering Journal, 2016
Young Investigator Award, Division of Biochemical Technology, American Chemical Society, 2015
Young Scientist Award, World Economic Forum (Tianjin, China), 2014
Alexander von Humboldt Fellowship for Experienced Researchers, 2014-2015
National Science Foundation CAREER Award, 2010-2015
Pew Scholar Award in Biomedical Sciences, 2010-2014
Rensselaer Dept. of Chemical & Biological Engineering Teaching Award, 2014
Rensselaer School of Engineering Teaching Excellence Award, 2013
Rensselaer Early Career Award, 2012
Rensselaer School of Engineering Research Excellence Award, 2012
Allan P. Colburn Lectureship, Univ. of Delaware, 2012
American Cancer Society Postdoctoral Fellowship, 2004-2007
NASA Graduate Fellowship, 1999-2002
Co-Valedictorian, Univ. of Maine, 1998
For a more complete list of Professor Tessier’s honors and awards and for additional information, please see his CV.
Select Journal Publications
Stimple, S.D., Kalyoncu, S., Desai, A.D., Mogensen, J.E., Spang, L.T., Asgreen, D.J., Staby, A., Tessier, P.M., “Sensitive detection of glucagon aggregation using amyloid fibril-specific antibodies”, Biotech Bioeng, ePub Apr 14, in press (2019).
Julian, M.C., Rabia, L.A., Desai, A.A., Arsiwala, A., Kane, R.S., Tessier, P.M., “Nature-inspired design and evolution of anti-amyloid antibodies”, J Biol Chem, 294, 8438 (2019).
Alam, M.E., Barnett, G.V., Slaney, T.R., Starr, C.G., Das, T.K., Tessier, P.M., “Deamidation can compromise antibody colloidal stability and enhance aggregation in a pH-dependent manner”, Mol Pharm, 16, 1939 (2019).
Starr, C.G., Tessier, P.M., “Selecting and engineering monoclonal antibodies with drug-like specificity”, Current Opin Biotech, 60, 119 (2019).
Rabia, L.A. Zhang, Y., Ludwig, S.D., Julian, M.C., Tessier, P.M., “Net charge of the complementarity-determining regions is a key predictor of antibody specificity”, Protein Eng Des Sel, 31, 409 (2018).
Rabia, L.A., Desai, A.A., Jhajj, H.S., Tessier, P.M., “Understanding and overcoming trade-offs between antibody affinity, specificity, stability and solubility”, Biochem. Eng. J., 137, 365 (2018).
Alam, M.E., Geng, S.B., Bender, C., Ludwig, S.D., Linden, L., Hoet, R., Tessier, P.M., “Biophysical and sequence-based methods for identifying monovalent and bivalent antibodies with high colloidal stability”, Mol Pharm, 15, 150 (2018).
Tiller, K.E., Li, L., Kumar, S., Julian, M.C., Garde, S., Tessier, P.M., “Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs”, J Biol Chem, 292, 16638 (2017).
Tiller, K.E., Chowdhury, R., Li, T., Ludwig, S., Sen, S., Maranas, C., Tessier, P.M., “Facile affinity maturation of antibody variable domains using natural diversity mutagenesis”, Front Immunol, 4, 986 (2017).
Julian, M.C., Li, L., Garde, S., Wilen, R., Tessier, P.M., “Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability”, Sci Rep, 7, 45259 (2017).
Geng, S.B., Wu, J., Schultz, J.S., Dickinson, C.D., Seminar, C.R., Alam, M.E., Tessier, P.M., “Facile preparation of stable antibody-gold conjugates and application to affinity-capture self-interaction nanoparticle spectroscopy”, Bioconjug Chem, 27, 2287 (2016).
Lee, C.C., Julian, M.C., Tiller, K.E., Meng, F., DuConge, S.E., Akter, R., Raleigh, D.P., Tessier, P.M., “Design and optimization of anti-amyloid domain antibodies specific for Aβ and IAPP”, J Biol Chem, 291, 2858 (2016).
Tiller, K.E., Tessier, P.M., “Advances in antibody design”, Ann Rev Biomed Eng, 17, 191 (2015).
Julian, M.C., Lee, C.L, Tiller, K.E., Rabia, L.A., Day, E.K., Schick III, A.J., Peter M. Tessier, “Co-evolution of affinity and stability of grafted amyloid-motif domain antibodies”, Protein Eng Des Sel, 28, 339 (2015).
Wu, J, Schultz, J.S., Weldon, C.L., Sule, S.V., Chai, Q., Dickinson, C.D., Tessier, P.M., “Discovery of highly soluble antibodies prior to purification using affinity-capture self-interaction nanoparticle spectroscopy”, Protein Eng Des Sel, 28, 493 (2015).
Li, X., Geng, S.B., Chiu, M.L., Saro, D., Tessier, P.M., “High-throughput assay for measuring monoclonal antibody self-association and aggregation in serum”, Bioconjug Chem, 26, 520 (2015).
Perchiacca, J.M., Lee, C.C, Tessier, P.M., “Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold”, Protein Eng Des Sel, 27, 29 (2014).
Sule, S.V., Dickinson, C.G., Lu, J., Chow, C.-K., Tessier, P.M., “Rapid analysis of antibody self-association in complex mixtures using immunogold conjugates”, Mol Pharm, 10, 1322 (2013).
Perchiacca, J.M., Ladiwala, A.R.A., Bhattacharya, M., Tessier, P.M., “Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions”, Protein Eng Des Sel, 12, 591 (2012).
Ladiwala, A.R, Litt, J., Kane, R.S., Aucoin, D.S., Smith, S.O., Ranjan, S, Davis, J., Van Nostrand, W.E., Tessier, P.M., “Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity”, J Biol Chem, 287, 24765 (2012).
Perchiacca, J.M., Tessier, P.M., “Engineering aggregation-resistant antibodies”, Ann Rev Chem Biomol Eng, 3, 263 (2012).
Perchiacca, J.P., Ladiwala, A.R.A, Bhattacharya, M.B., Tessier, P.M., “Structure-based design of conformation- and sequence-specific antibodies against amyloid β”, P Natl Acad Sci U S A, 109, 84 (2012).
Perchiacca, J.M., Bhattacharya, M., Tessier, P.M., “Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions”, Proteins, 79, 2637 (2011).