Associate Dean for Graduate & Professional Education (ADGPE)
University Diversity and Social Transformation Professor of Chemical Engineering
Miller Faculty Scholar
B-28 G072W NCRC
2800 Plymouth Road, Ann Arbor, MI 48109-2800
Cellular Adhesion and Drug Delivery Lab
University of Pennsylvania
PhD Chemical and Biomolecular Engineering ’04
MSE Chemical and Biomolecular Engineering ’00
University of Maryland, Baltimore County
BSE Chemical and Biomolecular Engineering ’99
Due to their high specific interaction with their counter-receptors and their carefully regulated expression (limit to inflammation), leukocyte-endothelium adhesion molecules (LECAM) are attractive molecules for vascular targeting in human diseases in which inflammation plays a role. Our research goal is to use knowledge of the cellular inflammatory response and blood flow dynamics to design bio-functionalized particles for targeted drug delivery and imaging.
Work in the lab is divided into 3 major groups:
- Cell Adhesion and Migration – Cells of the immune system.
Our goal is to use in vitro experimental setups to understand the receptor-ligand interactions involved in leukocyte firm arrest and transmigration.
- Design of polymeric cells for targeted drug delivery.
We are working on designing sophisticated leukocyte mimetics that can target therapeutics to diseased vasculature via multiple receptor-ligand interactions with applications in cardiovascular disease and cancer.
- Smart Biomaterials for Drug Delivery.
We working closely with polymer chemists and material scientist to identify new materials for drug delivery. Our work in this area is currently focused on immune response to new materials.
University of Michigan
Chemical Engineering Department
Ann Arbor, Michigan
Associate Professor, 2014-2017
Assistant Professor, 2006-2014
Baylor College of Medicine
Houston, Texas, 2004-2006
Undergraduate ChE Courses
ChE 230 – Material and Energy Balance, Fall 2009, Fall 2010
ChE 342 – Mass and Heat Transfer, Fall 2006, Fall 2007, Fall 2008
Graduate ChE Courses
ChE 696 – Engineering Principle in Drug Delivery and Targeting, Winter 2010
Senior Fellow, Michigan Society of Fellows, 2017
American Institute for Medical and Biological Engineering, Fellow, 2017
American Institute of Chemical Engineers, Women’s Initiatives Committee’s Mentorship Excellence Award, 2017
American Institute of Chemical Engineers, Minority Affairs Committee’s William W. Grimes Award for Excellence in Chemical Engineering, 2017
Raymond J. and Monica E. Schultz Outreach and Diversity Award, 2017
College of Engineering, University of Michigan
Harold R. Johnson Diversity Service Award (2016)
The University of Michigan
NAE Frontier of Engineering Education, Selected Participant (2012)
Provost Teaching Innovation Award (2012)
The University of Michigan
Departmental Research Achievement Award (2012)
Department of Chemical Engineering at the University of Michigan
NSF CAREER (2011)
National Science Foundation
Innovator Award (2010)
American Heart Association
Scientist Development Grant (2007)
American Heart Association
University of Michigan Rackham Faculty Development Grant, 2006
APS/NIDDK Travel Fellowship Awards: EB, 2006
Baylor College of Medicine NIH T32 Training Grant in Lung Disease, 2004 – 2006
Janice Lumpkin Awards For Excellence in Arts & Sciences, 2003
NASA Graduate Research Fellowship, 2002-2004
GEM Masters Fellowship in Engineering, 1999
UMBC Meyerhoff Scholarship, 1997-1999
UMBC MARC U* STAR Scholar, 1998 – 1999
- Heslinga, M.J., G.M. Willis, D. Sobzynski, A.J. Thompson and O. Eniola-Adefeso. (2013) “One-Step Fabrication of Agent-Loaded Biodegradable Microspheroids for Drug Delivery and Imaging Applications.” Submitted.
- Onyskiw, P. and O. Eniola-Adefeso. (2013) “Effect of PEGylation on Ligand-Based Targeting of Drug Carriers to the Vascular Wall in Blood Flow.” Langmuir. 2013. 29(35):11127-34.
- Thompson, A.J., E.M. Mastria, O. Eniola-Adefeso (2013) “The Margination Propensity of Ellipsoidal Micro/Nanoparticles to the Endothelium in Human Blood Flow” Biomaterials. 2013. 34(23):5863-71.
- Huang, R.B., A.L. Gonzalez, and O. Eniola-Adefeso. (2013) “Laminar Shear Stress Elicit Distinct Endothelial Cell E-Selectin Expression Pattern via TNFα and IL-1β Activation.” Biotechnology & Bioengineering. 2013. 110(3): 999-1003.
- Namdee, K., A.J. Thompson, P. Charoenphol and O. Eniola-Adefeso. (2013) “Margination propensity of vascular-targeted spheres from blood flow in a microfluidic model of human microvessels.” Langmuir. 2013. 29(8): 2530-2535.
- Charoenphol, P., P. Onyskiw and O. Eniola-Adefeso. (2012) “Particle-Cell Dynamics in Human Blood Flow: Implications for Vascular-Targeted Drug Delivery.” Journal of Biomechanics. 2012. 45(16):2822-2828.
- Heslinga, M.J., T.M. Porter and O. Eniola-Adefeso. Design of nanovectors for therapy and imaging of cardiovascular diseases. Methodists: Debakey Cardiovascular Journal, 2012. 8(1): 13-17.
- Huang, R.B. and O. Eniola-Adefeso. “Shear stress modulation of IL-1β-induced E-selectin expression in human endothelial cells.” PLoS One, 2012. 7(2): e31874.
- Charoenphol, P., S. Mocherla, D. Dubois, K. Namdee and O. Eniola-Adefeso. “Targeting therapeutics to the vascular wall in atherosclerosis – Carrier size matters.” Atherosclerosis, 2011. 217(2): 364-70.
- Huang, R.B., S. Mocherla, M.J. Heslinga, P. Charoenphol, and O. Eniola-Adefeso. “Dynamic and cellular interactions of nanoparticles in vascular-targeted drug delivery.” Molecular Membrane Biology, 2010. 27(4-6): 190-205. Second most read article summer 2010.
- Eniola-Adefeso, O. Bringing Outreach Into the Engineering Classroom – A Mass and Heat Transfer Course Project. Chemical Engineering Education, 2010. 44(4): 280.
- Charoenphol, P., R.B. Huang and O. Eniola-Adefeso. “Potential role of size and hemodynamics in the efficacy of vascular-targeted spherical drug carriers.” Biomaterials, 2010. 31(6): 1392-402.
- Heslinga, M.J., E.M. Mastria* and O. Eniola-Adefeso. Fabrication of biodegradable spheroidal microparticles for drug delivery applications. Journal of Controlled Release, 2009. 138(3): 235-242.
- Eniola-Adefeso, O., R.B. Huang and C.W. Smith. Kinetics of LFA-1 Mediated Adhesion of Human Neutrophils to ICAM-1 – Role of E-Selectin Signaling Post-Activation. Annals of Biomedical Engineering, 2009. 37(4): 737-48.
- Eniola, A.O. and D.A. Hammer. In vitro characterization of leukocyte mimetic for targeting therapeutics to the endothelium using two receptors. Biomaterials, 2005. 26(34): 7136-44.
- Eniola, A.O., E.F. Krasik, L.A. Smith, S. Gang, and D.A. Hammer. I-domain of lymphocyte function-associated antigen-1 mediates rolling of polystyrene particles on ICAM-1 under flow. Biophysical Journal, 2005. 89: 3577-88.
- Eniola, A.O. and D.A. Hammer. Characterization of biodegradable drug delivery vehicles with the adhesive properties of leukocytes II: Effect of degradation on targeting efficiency. Biomaterials, 2005. 26(6): 661-670.
- Eniola, A.O., P.J. Willcox and D.A. Hammer. Quantifying Interplay between rolling and firm adhesion elucidated with a cell-free system engineered with two distinct receptor-ligand pairs. Biophysical Journal, 2003. 85(4): 2720-31.
- Zhang, Y., A.O. Eniola, D.J. Graves, and D.A. Hammer. Specific Adhesion of Micron-Sized Colloids to Surfaces Mediated by DNA Hybridization. Langmuir, 2003. 19(17): 6905-11.
- Eniola, A.O. and D.A. Hammer. Artificial polymeric cells for targeted drug delivery. Journal of Controlled Release, 2003. 87(1-3): 18-22.
- Eniola, A.O., S.D. Rodgers and D.A. Hammer. Characterization of biodegradable drug delivery vehicles with the adhesive properties of leukocytes. Biomaterials, 2002. 23(10): 2167-77.
- Eniola, A.O. and J.A. Lumpkin. Reducing metal-catalyzed oxidation during immobilized Cu-Iminodiacetic acid metal affinity chromatography. Proceedings National Conference of Undergraduate Research, 1998. Volume III: 989-91.