image of Jean-Marie Rouillard

Jean-Marie Rouillard

Associate Research Scientist


[email protected]

(734) 763-4722


Chemical Engineering

B-28 1052W
2800 Plymouth Road, Ann Arbor, MI 48109-2800


Centre de Génétique Moléculaire du CNRS; Gif-sur-Yvette, France
Genetics and Molecular Biology ’98

University of Paris XI
M. Sc. Molecular Biology and Genetics ’93
B. Sc. Biochemistry ’85


Professional Experience

University of Michigan
Chemical Engineering Department
Ann Arbor, Michigan

Assistant Research Scientist, 2007-
Research Investigator, 2003-2007
Research Fellow (w/ Erdogan Gulari), 2001-2003
Research Fellow (w/ S. Hanash), 2000-2001


J.-M. Rouillard, M.-E. Dufour, B. Theunissen, E. Mandart, G. Dujardin, and F. Lacroute, 1996. sls1, a new Saccharomyces cerevisiae gene, involved in mitochondrial metabolism, isolated as a synthetic lethal in association with an SSM4 deletion. Mol Gen Genet, 252, 700-708.

J.-M. Rouillard, C. Brendolise and F. Lacroute, 2000. Rna14p, a component of the yeast nuclear Cleavage/Polyadenylation Factor I, is also localised in mitochondria. Mol Gen Genet 262(6):1103-12.

J.-M. Rouillard, A. Erson, R . Kuick, J. Asakawa, K. Wimmer, M. Muleris, E. Petty and S. Hanash, 2001. Virtual Genome Scan: A Tool for Restriction Landmark Based Scanning of the Human Genome. Genome Research, 11(8):1453-1459.

J. Oh, F. Brichory, E. Puravs, R. Kuick, C. Wood, J.-M. Rouillard, J. Tra, S. Kardia, D. Beer and S. Hanash, 2001. A database of protein expression in lung cancer. Proteomics, 1, 1303-1319.

A. Erson, B Niell, S. DeMers, J.-M. Rouillard, S. Hanash and E. Petty, 2001. Characterization of two distinct amplicons on 17q23 and overexpression of TRE2 in breast cancer. Neoplasia, 3(6):521

S. Hanash, M. Bobek, D. Rickman , T. Williams, J.-M. Rouillard, R. Kuick, E. Puravs, 2002. Integrating cancer genomics and proteomics in the post-genome era. Proteomics. 2(1):69-75.

M. Ehrlich, K. Buchanan, F. Tsien, G. Jiang, B. Sun, W. Uicker, C. Weemaes, D. Smeets, K. Sperling, B. Belohradsky, D. Misek, J.-M. Rouillard, R. Kuick and S. Hanash, 2001. DNA Methyltransferase 3B Mutations Linked to the ICF Syndrome Cause Dysregulation of Lymphogenesis genes. Human Molecular Genetics, 10(25), 2917-2931.

K. Wimmer, X.-X. Zhu, J.-M. Rouillard, P. Ambros, B. Lamb, R. Kuick, M. Eckart, A. Weinhausl, C. Fonatsch and S. Hanash, 2002. Combined Restriction Landmark Genomic Scanning and Virtual Genome Scans identify a novel human homeobox gene, Alx3, that is hypermethylated in neuroblastoma. Genes Chromosomes and Cancer, 33(3):285-94.

J.-M Rouillard, C. Herbert and M. Zuker, 2002. OligoArray: Genome-scale oligonucleotide design for microarrays. Bioinformatics, 18(3):486-7.

C. Brendolise, J.-M. Rouillard, M.-E.Dufour and F. Lacroute, 2002. Expression analysis of RNA14, a gene involved in mRNA 3′ end maturation in yeast: characterization of the rna14-5 mutant strain. Mol Genet Genomics, 267(4):515-25.

R. Wu, L. Lin, D. Beer, L. Ellenson, B. Lamb, J.-M. Rouillard, R. Kuick, S. Hanash, D. Schwartz, E. Fearon and K. Cho, 2003. Amplification and Overexpression of the L-MYC Proto-Oncogene in Ovarian Carcinomas. Am J Pathol, 162(5):1603-10.

J.-M. Rouillard, M. Zuker and E. Gulari, 2003. OligoArray 2.0: design of oligonucleotide probes for DNA microarrays using a thermodynamic approach. Nucleic Acids Res, 31(12):3057-62.

C. Creighton, R. Kuick, D. Misek, D. Rickman, F. Brichory, J.-M. Rouillard, G. Omenn, S. Hanash, 2003. Profiling of pathway-specific changes in gene expression following growth of human cancer cell lines transplanted into mice. Genome Biol, 4(7):R46.

J.-M. Rouillard, M. Zuker and E. Gulari, 2003. OligoArray 2.0: design of oligonucleotide probes for DNA microarrays using a thermodynamic approach. Nucleic Acids Res, 31(12):3057-62.

A. Zatkova, J-M Rouillard, W. Hartmann, B. Lamb, R. Kuick, M. Eckart, D. Von Schweinitz, A. Koch, C. Fonatsch, T. Pietsch, S. Hanash, and K Wimmer, 2004. Amplification and Overexpression of the IGF2 Regulator PLAG1 in Hepatoblastoma. Genes, Chromosomes and Cancer, 39(2):126-37.

A. Zatkova, R. Ullmann, J.-M. Rouillard, B. Lamb, R. Kuick, S. Hanash, S. Schnittger, C. Schoch, C. Fonatsch and K. Wimmer, 2004. Distinct sequences on 11q13.5 and 11q23-24 are frequently coamplified with MLL in complexly organized 11q amplicons in AML/MDS patients. Genes Chromosomes Cancer, 39(4):263-76.

J.-M. Rouillard, W. Lee, G. Truan, X. Gao, X. Zhou, E. Gulari, 2004. Gene2Oligo: Oligonucleotide design for in vitro gene synthesis. Nucleic Acids Res, 32:W176-80.

V. Denef, J. Park, T. Tsoi, J.-M. Rouillard, H. Zhang, J. Wibbenmeyer, W. Verstraete, E. Gulari, S. Hashsham, J. Tiedje, 2004. Biphenyl and benzonate metabolism in a genomic context: outlining genome-wide metabolic networks in Burkholderia xenovorans LB400. Appl Environ Microbiol, 70(8):4961-70.

X. Zhou, S. Cai, A. Hong, Q. You, P. Yu, N. Sheng, O. Srivannavit, S. Muranjan, J.-M. Rouillard, Y Xia, X. Zhang, Q. Xiang, R. Ganesh, Q. Zhu, A. Matejko, E. Gulari, X. Gao, 2004. Microfluidic PicoArray synthesis of oligodeoxynucleotides and simultaneous assembling of multiple DNA sequences. Nucleic Acids Res, 32(18):5409-17.

S. Hashsham, L. Wick, J.-M. Rouillard, E. Gulari, J. Tiedje, 2004. Potential of DNA microarrays for developing parallel detection tools (PDTs) for microorganisms relevant to biodefense and related research needs. Biosensors and Bioelectronics, 20(4):668-83.

P. Podsiadlo, S. Paternel, J.-M. Rouillard, Z. Zhang, J. Lee, JW. Lee, E. Gulari, N. Kotov, 2005. Layer-by-layer assembly of nacre-like nanostructured composites with antimicrobial properties. Langmuir, 21(25):11915-21.

L. Wick, J.-M. Rouillard, T. Whittam, E. Gulari, J. Tiedje, S. Hashsham, 2006. On-chip non-equilibrium dissociation curves and dissociation rate constants as methods to assess specificity of oligonucleotide probes. Nucleic Acids Res., 34(3):e26.

K. Le Brigand, R. Russell, C. Moreilhon, J.-M. Rouillard, B. Jost, F. Amiot, V. Magnone, C. Bole-Feysot, P. Rostagno, V. Virolle, V. Defamie, P. Dessen, G. Williams, P. Lyons, G. Rios, B. Mari, E. Gulari, P. Kastner, X. Gidrol, T.C. Freeman and P. Barbry, 2006. An open-access long oligonucleotide microarray resource for analysis of the human and mouse transcriptomes. Nucleic Acids Res., 34(12):e87.

R. Stedtfeld, L. Wick, SW Baushke, D. Tourlousse, A. Herzog, Y. Xia, J.-M. Rouillard, J. Klappenbach, J. Cole, E. Gulari, J. Tiedje, S. Hashsham, 2006. Influence of Dangling End and Surface Proximal Tail of Targets on Probe-Target Duplex Formation in 16S rRNA Gene-Based Diagnostic Arrays. Appl Environ Microbiol. 2006 Nov 17; [Epub ahead of print]