Sasha Cai Lesher-Pérez

Sasha Cai Lesher-Pérez

Assistant Professor


[email protected] 



NCRC-B28 3006E (Faculty Office)
NCRC-B28 2095E (Research Lab)

Personal Pronouns

He / Him / His

Primary Website

Lesher-Pérez Research Group


University of Michigan
PhD, Biomedical Engineering, 2015
Thesis: Development of Micro-actuators and Micro-sensors for the On-chip Interrogation of Cells and In Vitro Generated Tissues.

MSE, Biomedical Engineering, 2010

University of Wisconsin-Madison
BSE, Biomedical Engineering and Mathematics, 2008

Research Interests


Professional Experience

University of Michigan
Chemical Engineering Department
Ann Arbor, Michigan
Assistant Professor, starting in 2022

Intelligent Optical Systems
Torrance, California
Biomedical Engineer, Senior Scientist, 2021

Marie Curie H2020
Elvesys SAS, Paris, France
Individual Fellow, 2018 – 2019

University of California
Los Angeles, CA
Research Advisor: Tatiana Segura, Ph.D.
Postdoctoral Associate, 2015 – 2018


NextProf Future Faculty Program, 2020
SHPE Faculty Development Symposium Travel Grant, 2019
Horizon 2020 Framework Programme Marie Skłodowska-Curie Actions, 2017
Independent Fellowship – H2020-MSCA-IF-2016 Recipient
Ford Foundation Postdoctoral Fellowship, 2017
National Institute of Neurological Disorders and Stroke F31 Grant (Diversity Supplement), 2015


See Google Scholar for full list of publications

*- equal contribution, # – corresponding author; ^ – undergrad student; PhD student; graduated PhD student

  1. Sharan, P., Nsamela, A., Lesher-Pérez, S.C., Simmchen, J.# Microfluidics for microswimmers: engineering novel swimmers and constructing swimming lanes on the microscale, a tutorial review. Small. 2021. 17, 2007403
  2. McMillan, A. H., Alcaine, C., Teyssandier, J., Thür, R., Roy, E., Ochoa, I., Roeffaers, M.B.J., Lesher-Pérez, S.C.#, Self-sealing thermoplastic fluoroelastomer enables rapid fabrication of modular microreactors. Nano Select. 2021. 2, 1385-1402.
  3. McMillan, A.H., Dellaquila, A., Thomee, E.K., Nassman, H., Segura, T., Lesher-Pérez, S.C.# Rapid fabrication of membrane-integrated thermoplastic elastomer microfluidic devices. Micromachines, 2020. 11, 731, DOI: 10.3390/mi11080731
  4. Truong, N., Lesher-Pérez, S.C., Kurt, E., Segura, T.# Pathways governing polyethylenimine polyplex transfection in microporous annealed particle scaffolds. Bioconjugate Chemistry. 2018. 30, 476-486
  5. Lesher-Pérez, S.C., Zhang, C., Takayama, S. # Capacitive coupling synchronizes autonomous microfluidic oscillators. Electrophoresis. 2018. 39, 1096-1103
  6. Lesher-Pérez, S.C., Kim, G.-A.; Kuo, C, Leung, B.M., Mong, S.^, Kojima, T., Moraes, C., Thouless, M.D., Luker, G.D., Takayama, S.# Dispersible oxygen microsensors map oxygen gradients in three-dimensional cell cultures. Biomaterials Science. 2017. 5, 2106-2113
  7. Kim, S., Lesher-Perez, S.C., Kim, B.-C., Yamanishi, C., Labuz, J.M., Leung, B.M., Takayama, S. # Pharmacokinetic profile that reduces nephrotoxicity of gentamicin in a perfused kidney-on-a-chip. Biofabrication. 2016, 8, 015021
  8. Lesher-Perez, S.C., Segura, T., Moraes, C. # Getting there is half the battle: recent advances in delivering therapeutics. Integrative Biology. 2016, 8, 8-11
  9. Kim, S.-J., Yokokawa, R., Lesher-Perez, S.C., Takayama, S.# Multiple independent autonomous hydraulic oscillators driven by a common gravity head. Nature Communications. 2015, 6, 7301
  10. Frampton, J., Leung, B., Bingham, E., Lesher-Perez, S.C., Wang, Sarhan, H.T., J., El-Sayed, M., Feinberg, S., Takayama, S.# Rapid self‐assembly of macroscale tissue constructs at biphasic aqueous interfaces. Advanced Functional Materials. 2015, 25, 1694-1699
  11. Lesher-Perez, S.C., Weerappuli, P., Zhang, C., Kim, S.-J., Takayama, S.# Predictable duty cycle modulation through coupled pairing of syringes with microfluidic oscillators. Micromachines. 2014, 5, 1254-1269
  12. Leung, B.M., Lesher-Perez, S.C., Matsuoka, T., Moraes, C., Takayama, S.# Media additives to promote spheroid circularity and compactness in hanging drop platform. Biomaterials Science. 2014, 3, 336-44
  13. Lesher-Perez, S.C., Frampton, J.P., Takayama, S.# Microfluidic systems: A new toolbox for pluripotent stem cells. Biotechnology Journal. 2013, 8, 180-191
  14. Kim,S.-J., Yokokawa, R., Lesher-Perez, S.C., Takayama, S.# Constant flow-driven microfluidic oscillator for different duty cycles. Analytical Chemistry. 2012, 84, 1152-1156
  15. Moraes, C., Mehta, G., Lesher-Perez, S.C.*, Takayama, S.# Organs-on-a-chip: a focus on compartmentalized microdevices. Annals of Biomedical Engineering. 2012, 40, 1211-1227