The research will involve developing and optimizing bifunctional antibodies, which target one molecule at the blood-brain barrier for transport into the brain and a second molecule in the brain to mediate neuroprotective function.
$3.8M grant supports protein engineering technologies that improve brain delivery of neuroprotective antibodies for treating Alzheimer’s disease
Behind the Paper: Enabling Multi-Objective Antibody Optimization
This PhD student blog post explores the use of machine learning for simultaneously optimizing antibody affinity and specificity, which could help accelerate drug development.
New protein engineering method could accelerate the discovery of COVID-19 therapeutics
The method could one day be used to develop nanobodies against other viruses and disease targets as well.